In Colombiana 2, Cataleya (Zoe Saldana) resurfaces after years in hiding, drawn back into the underworld when a mysterious assassin, Marcus Kane (Jason Statham), begins eliminating her former allies. Initially enemies, Cataleya and Marcus discover they share a common target—an international arms syndicate responsible for both their tragic pasts.

Reluctantly teaming up, their missions collide in a global chase from Bogotá to Eastern Europe. As trust builds, so does tension, both romantic and deadly. Betrayals and bloodshed mount until Cataleya faces a choice: complete her revenge or protect a young girl caught in the crossfire, mirroring her own lost innocence.